Rythmosin

Introduction
Rythmosin is a medicine used to treat arrhythmia (abnormal heart rhythm). It restores normal heart rhythm by blocking abnormal electrical signals in the heart. This helps to maintain a regular and steady heartbeat. Rythmosin should be taken regularly as advised by the doctor. You should take it with food and at a fixed time. This medicine should not be stopped abruptly without consulting the doctor as this can worsen your condition. Regular follow-up with your doctor is advised while using this medicine. It may cause side effects like dizziness, headache, blurred vision, nausea, constipation and fatigue in some patients. Your doctor may advise for regular monitoring of kidney function while you are taking this medicine. This medicine may not be suitable for some people. You must inform doctor if you are suffering from any liver or kidney disease. Also let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it.

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Uses of Rythmosin
Arrhythmia
Side effects of Rythmosin
Common
Abdominal pain
Anxiety
Blurred vision
Breathlessness
Chest pain
Constipation
Dizziness
Dryness in mouth
Fatigue
Fever
Headache
Increased liver enzymes
Palpitations
Sleep disorder
Taste change
Visual impairment
Vomiting
Weakness
How to use Rythmosin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rythmosin is to be taken with food.
How Rythmosin works
Rythmosin is an anti-arrhythmic medication. It works by blocking abnormal electrical signals in the heart to correct irregular heartbeat to a normal rhythm.
What if you forget to take Rythmosin?
If you miss a dose of Rythmosin, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
It may cause dizziness. Do not drive or perform activities require mental focus until you know how it affects you.
Do not start any medicine including prescription or over-the-counter medicines without informing your doctor, as they may alter Rythmosin levels in your body.
Your doctor may get blood tests done to check your sodium and potassium levels, kidney function, and lung function before starting treatment with this medicine.
Your doctor may regularly monitor blood sugar level while taking this medicine.
Inform your doctor if you experience slow or fast heart rate, chest pain, shortness of breath.
Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Do not stop taking medication suddenly without talking to your doctor.
Brief Description
Indication
Supraventricular and ventricular arrhythmias, Atrial Fibrillation/Flutter
Administration
Should be taken with food. Take after meals. Swallow whole, do not chew/crush.
Adult Dose
Oral Supraventricular and ventricular arrhythmias, Atrial Fibrillation/Flutter Adult: For immediate-release tablet: Usual initial doses: 150 mg tid, may increase at intervals of 3-4 days up to 300 mg tid. Dose reduction is recommended in patients weighing <70 kg. Elderly: Dose reduction is recommended. Hepatic impairment: Dose reduction is recommended. _ Child Dose Safety and efficacy not established _ Contraindication Uncontrolled heart failure, marked hypotension, severe bradycardia and heart block, conduction abnormalities, cardiogenic shock, myasthenia gravis. Mode of Action Propafenone is a class 1C antiarrhythmic drug with local anaesthetic effects, and a direct stabilising action on myocardial membranes. The electrophysiological effect manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. Precaution Severe pulmonary obstructive diseases, CHF, cardiac pacemaker, impaired renal/hepatic function, pregnancy, lactation, elderly. Correct electrolyte disturbances before starting treatment. May worsen heart failure in patients with preexisting organic heart disease. May worsen or cause new severe ventricular arrhythmias e.g. ventricular tachycardia or fibrillation. May aggravate electrically induced ventricular tachycardia in some patients. Lactation: Crosses into breast milk; discontinue drug or do not nurse _ Side Effect >10% Unusual taste (7-23%),Dizziness/lightheadedness (7-15%),N/V (3-11%) 1-10% Constipation (4-8%),Headache (2-6%),Intraventricular conduction delay (4%),Fatigue (6%),Blurred vision (3%),Weakness (3%),Dyspnea (2%),Wild complex tachycardia (2%),Bradycardia (2%),Palpitations (2%),Tremor (2%),Anorexia (2%),Diarrhea (2%),Ataxia (2%),1°AV block (2-5%),Angina (5%),Palpitations (3%),CHF (2-3% ),Chest pain (2%),Bradyarrhythmia (2%),AF (1%),Bundle branch block (1%),2nd degree AV block (1%),Hypotension (1%),Sinus arrest (1%) Frequency Not Defined Lethargy,Rash,Dyspepsia,Dry mouth,Agranulocytosis,Hepatotoxicity (rare),Systemic lupus erythematosus (rare),Bronchospasm (rare) Potentially Fatal: SA/AV or intraventricular blocks. Severe hypotension, especially in elderly.

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Interaction
Effect may be potentiated by local anesth, beta-blockers, TCA. May increase plasma level of propranolol, metoprolol, desipramine, cyclosporin, digoxin, theophylline. Plasma conc may rise when taken simultaneously w/ cimetidine or quinidine. May enhance effect of anticoagulant. Simultaneous administration w/ phenobarb or rifamycin may decrease propafenone plasma conc, possibly in sub-therapeutic levels.