Stener 150

Introduction
Stener 150 is a medicine used to dissolve certain types of gallstones, to prevent them from forming and to treat a type of liver disease called primary biliary cirrhosis. It is a bile acid which helps break down cholesterol which has formed into stones in your gallbladder. Stener 150 should be taken after a meal with a glass of milk or water. The dose will depend on what you are being treated for and your body weight. It would be best to swallow it whole. This medicine needs to be taken regularly to get the most benefit and you may have to take it for several months or longer, so try to get into a routine. Keep using it as prescribed even if your symptoms disappear. Even if the gallstones completely dissolve, the treatment should still be continued for several weeks or months. The most common side effects are diarrhea, stomach upset or pain, nausea, dizziness, back pain or hair loss. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Before taking this medicine, you should tell your doctor if you have an inflammation of the gallbladder or bile ducts, you get frequent cramp-like pain in your upper abdomen, you have been coughing up blood or you have gained weight rapidly. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor all other medicines you are taking. Women who use this medicine for dissolving gallstones should stop using the birth control pill because the hormones present in it can increase the production of gallstones. During the treatment, you may need ultrasound scans, or frequent blood tests to check your liver function.

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Uses of Stener 150
Primary biliary cirrhosis
Gallbladder stones
Side effects of Stener 150
Common
Abdominal pain
Diarrhea
Hair loss
Itching
Nausea
Rash
How to use Stener 150
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Stener 150 is to be taken with food.
How Stener 150 works
Stener 150 is a hepatoprotective medication. It works by reducing the amount of cholesterol in the blood and helps dissolve gallbladder stones that are composed mainly of cholesterol. It also improves liver enzymes, protects liver cells from injury caused due to toxic bile acids, and improves liver function.
What if you forget to take Stener 150?
If you miss a dose of Stener 150, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
Stener 150 should be taken after a meal with a glass of milk or water.
Eat a healthy diet, exercise regularly and avoid alcohol intake.
Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
Your doctor may monitor your liver function and bilirubin levels every month for next 3 months after the start of therapy, and every 6 months thereafter.
Do not stop taking the medication without talking to your doctor.
Brief Description
Indication
Dissolution of cholesterol-rich gallstones, Primary biliary cirrhosis, Prevention of gallstone formation in obese patients experiencing rapid weight loss,
Administration
Should be taken with food.
Adult Dose
Oral Dissolution of cholesterol-rich gallstones Adult: 8-12 mg/kg once daily at bedtime or in 2 divided doses continued for 3-4 mth after radiological disappearance of gallstones. Duration of treatment: Up to 2 yr. Obese patients: Up to 15 mg/kg daily. Primary biliary cirrhosis Adult: 10-16 mg/kg daily in 2-4 divided doses, may be taken once daily in the evening after the 1st 3 mth. Prophylaxis of gallstones in patients undergoing rapid weight loss Adult: 300 mg bid. Non-alcoholic fatty liver disease: 13-15 mg/kg/day;

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Contraindication
Acute inflammation of gallbladder or biliary tract, occlusion of biliary tract, frequent episodes of biliary colic, radio-opaque calcified gallstones, impaired contractility of gallbladder, non-functioning gallbladder, inflammatory bowel disease, hepatic and intestinal conditions interfering w/ enterohepatic recirculation of bile acids, extrahepatic and intrahepatic cholestasis, ileal resection and stoma, regional ileitis, active duodenal and gastric ulcer; acute, chronic or severe hepatic disease.
Mode of Action
Ursodeoxycholic acid suppresses hepatic synthesis and secretion of cholesterol and also inhibits intestinal absorption of cholesterol.
Precaution
Excessive diatery intake of calories and cholesterol should be avoided. Liver function tests and bilirubin levels should be monitored every month for three months after start of therapy. 50% of successfully treated patients will develop further gallstones within 10 yr. Pregnancy and lactation. Monitoring Parameters Monitor LFTs mthly for the 1st 3 mth and every 6 mth thereafter. Lactation: unknown if excreted in breast milk; use caution

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Side Effect
>10% Headache,Dizziness,Diarrhea,Dyspepsia,Nausea/vomiting,Back pain,Upper respiratory tract infection 1-10% Alopecia,Rash,Hyperglycemia,Flatulence,Peptic ulcer,Urinary tract infection,Leukopenia,Thrombocytopenia,Cholecystitis >1% Fatigue,Abdominal pain,Thrombocytopenia,Pruritus,Angioedema,Peripheral edema,Biliary pain

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Interaction
Cholestyramine, charcoal and antacids may reduce effectiveness. Aluminum-based antacids may reduce absorption. Oestrogens and clofibrate may counteract effectiveness of ursodeoxycholic acid by increasing cholesterol elimination in bile. Possible increase in ciclosporin serum concentration. Decreased effectiveness of dapsone. Possible decrease in serum ciprofloxacin and nitrendipine.
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Stener 150
Tablet
– (150mg)
arogga-brand
Healthcare Pharmaceuticals Ltd.
Generic: Ursodeoxycholic Acid
10 Tablets (1 Strip)
৳ 139.22
৳ 150
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