Medicine Overview of Suvorest 10mg Tablet
Insomnia
Recommended starting dose: 10 mg PO taken no more than once per night and within 30 minutes of going to bed.
Not to exceed 20 mg once daily.
Hepatic impairment
Mild-to-moderate: No dosage adjustment required
Severe: Not recommended
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Orexin receptor antagonist; orexin, also called hypocretin, is a neurotransmitter that regulates arousal, wakefulness, and appetite
Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive
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Can impair daytime wakefulness; CNS depressant effects can last for up to several days after discontinuation
Can impair driving skills and may increase the risk of falling asleep while driving
Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary when administered together because of potentially additive effects
Use with other drugs to treat insomnia is not recommended
Risk of next-day impairment, including impaired driving, is increased if taken with less than a full night of sleep remaining, if a higher than the recommended dose is taken, if coadministered with other CNS depressants, or if coadministered with other drugs that increase suvorexant blood levels
Dose-dependent increase in suicidal ideation was observed in patients taking suvorexant, as assessed by questionnaire; immediately evaluate patients with suicidal ideation or any new-onset behavioral changes; worsening depression or suicidal thinking, thoughts, and actions have been reported with the use of sedative-hypnotic
Consider effect on respiratory function
Risk of sleep paralysis, hypnagogic/hypnopompic hallucinations, and cataplexy-like symptoms increases with increasing doses
Not recommended for patients with severe hepatic impairment
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1-10%
Somnolence, females (8%),Somnolence (7%),Headache (7%),Somnolence, males (3%),Dizziness (3%),Abnormal dreams (2%),Cough (2%), Diarrhea (2%),Dry mouth (2%),Upper respiratory tract infection (2%)
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