Medicine Overview of Tericin 50mg/vial Injection
Tericin is an antifungal medication. It is used in the treatment of severe fungal infections and kala-azar. It kills the infection causing fungi and thus, treats the infection.
Tericin is administered as an injection by a healthcare professional. Kindly do not self administer. Before you take this medicine, inform your doctor if you suffer from diabetes, liver/kidney problems or are on dialysis or have low potassium level in blood.
It may lead to a few common side effects like headache, vomiting, nausea, stomach cramps and fever. You may also notice some injection site reactions like pain, swelling or redness. Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding.
- Severe fungal infections
- Kala-azar
- Headache
- Vomiting
- Nausea
- Stomach cramp
- Fever
- Anemia (low number of red blood cells)
- Heartburn
- Hyperventilation (rapid breathing)
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It is usually given as an injection over 1-2 hours under the supervision of a medical professional.
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Tericin can cause rash, chills, headache, and tiredness during initial days of the treatment, but these may fade away with time.
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Your doctor may ask you for regular blood tests to monitor your blood sugar, potassium, magnesium and kidney function.
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Inform your doctor immediately if you notice pain or blood upon urination, swelling of the face and trouble breathing.
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Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Adult: Dosing regimens are applicable to amphotericin B (conventional). PO Oral candidiasis Per loz contains amphotericin B 10 mg: Suck 1 loz 4 times/day, up to 8 loz/day if needed.
IV Systemic Fungal Infections
Test dose: 1 mg IV x1 infused over 20-30 min
Load: 0.25-0.5 mg/kg IV infused over 2-6 hr
Maintenance: 0.25-1 mg/kg IV qDay OR up to 1.5 mg/kg IV qOD (may increase gradually by 0.25 mg-increments/day)
Increased toxicity with flucytosine. Drug induced renal toxicity enhanced in presence of other nephrotoxic medications. Antagonises effects of azole antifungals.
Potentially Fatal: Potentiates K loss by corticosteroids. Avoid diuretics. Enhances digitalis toxicity and neuromuscular blocker effects.
Renal and hepatic impairment; pregnancy; monitor renal and liver function changes.
Lactation: Excretion in milk is unknown; due to the potential for serious adverse reactions in breast-fed infants, a decision should be made whether to discontinue nursing or whether to discontinue the drug, taking into account the importance of the drug to the mother
Systemic Fungal Infections
Test dose: 0.1 mg/kg IV, not to exceed 1 mg; administer over 20-60 min
Initial dose: 0.25 mg/kg/dose IV qDay/qOD
Maintenance: Increase by 0.25 mg/day increments as tolerated to 1-1.5 mg/kg/day
IV Administration
Use promptly after dilution. Infuse over 2-6 hr
Reconstitution: For conventional amphotericin B: Reconstitute with sterile water for inj (without preservatives), then further dilute with glucose inj 5% (with a pH>4.2) to a final concentration not exceeding 0.1 mg/ml for peripheral infusion or 0.25 mg/ml for central infusion.
Renal Impairment
CrCl <10 mL/min: 0.5-0.7 mg/kg IV q24-48hr
Consider other antifungal agents that may be less nephrotoxic
Intermittent hemodialysis: 0.5-1 mg/kg IV q24hr after dialysis session
Continuous renal replacement therapy: 0.5-1 mg/kg IV q24hr
>10%
Anorexia,Chills,Diarrhea,Fever,Headache,Hypokalemia,Hypomagnesemia,Hypotension,Malaise,Nausea,Pain (generalized),Pain at injection site,Renal function abnormalities,Tachypnea,Vomiting
1-10%
Arachnoiditis,Delerium,Flushing,Hypertension,Leukocytosis,Lumbar nerve pain,Paresthesia,Urinary retention
<1%
Agranulocytosis,Anuria,Bone marrow suppression,Cardiac arrest,Coagulation defects,Convulsions,Dyspnea,Hearing loss,Leukopenia,Maculopapular rash,Renal failure,Thrombocytopenia,Vision changes
Potentially Fatal: Anaphylactic reaction; leucoencephalopathy. Overdosage can result in cardio-respiratory arrest.
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