Thiocil 50

Introduction
Thiocil 50 belongs to a group of medicine called anti-thyroid agents. It is used in the treatment of hyperthyroidism. It works by reducing the production of a hormone called thyroxine by the thyroid gland. Thiocil 50 may be used alone or in combination with other medicines. It can be taken with or without food. It should be taken exactly as prescribed by your doctor. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel better unless the doctor tells you so. Taking this medicine may cause few common side effects such as skin rash, headache, skin pigmentation, nausea, and muscle pain or weakness. Let your doctor know if any of these side effects do not go away with time or get worse. Before using this medicine, inform your doctor if you have any problems with your liver or kidneys. You should also tell your doctor all the other medications you are taking. Pregnant and breastfeeding mothers should consult their doctors before using the medicine.

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Uses of Thiocil 50
Hyperthyroidism
Side effects of Thiocil 50
Common
Skin rash
Hair loss
Headache
Pain
Joint stiffness
Nausea
Skin pigmentation
Paresthesia (tingling or pricking sensation)
How to use Thiocil 50
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Thiocil 50 may be taken with or without food, but it is better to take it at a fixed time.
How Thiocil 50 works
Thiocil 50 is an anti-thyroid medication. It works by reducing the amount of thyroid hormones produced by the thyroid gland.
Quick Tips
PTU Tablet is used for the treatment of hyperthyroidism.
You may have to stop taking it for a while if you are also taking radio-iodine as a treatment for your overactive thyroid.
It may affect the level of blood cells in your blood. Inform your doctor if you experience symptoms such as unexplained bruising or bleeding, sore throat, mouth ulcers, fever, or general illness.
Stop taking PTU Tablet and Inform your doctor if you develop symptoms of liver damage such as abdominal pain, loss of appetite, darkened urine or yellowing of the eyes or skin.
Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
Brief Description
Indication
Hyperthyroidism
Administration
Should be taken with food.
Adult Dose
Oral Hyperthyroidism Adult: 150-450 mg daily in divided doses. For severe cases, initial doses of 600-1200 mg daily have been used. Maintenance dose for euthyroid patients: 50-150 mg daily. Treatment is usually continued for 1-2 yr. Hepatic impairment: Dose reduction is recommended.

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Child Dose
Oral Hyperthyroidism Child: Neonates: 2.5-5 mg/kg bid; 1 mth-1 yr: 2.5 mg/kg tid; 1-5 yr: 25 mg tid; 5-12 yr: 50 mg tid; 12-18 yr: 100 mg tid.

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Renal Dose
Renal impairment: CrCl (ml/min) Dosage Recommendation <10 Reduce dose by 50%. 10-50 Reduce dose by 25%. _ Contraindication Hypersensitivity, pregnancy, lactation. Mode of Action Propylthiouracil inhibits the production of thyroid hormones by preventing iodine from being oxidised in the thyroid gland. It also blocks the peripheral deiodination of thyroxine to tri-iodothyronine. Precaution Reserve use for patients unable to tolerate any other treatments e.g. methimazole, radioactive iodine or surgery. Inform patient of liver failure risk and to report any signs of liver dysfunction (e.g. loss of appetite, nausea, vomiting, pruritus, dark coloured urine, light coloured stools, jaundice, right upper-quadrant pain) or agranulocytosis (e.g. fever, sore throat) immediately. Stop treatment upon signs of agranulocytosis, aplastic anaemia, fever, liver injury, elevated LFT above 3 times the upper limit of normal, or exfoliative dermatitis. Regular monitoring of thyroid function and CBC is advisable. Monitor prothrombin time regularly during treatment, especially before surgical procedures. Lactation: distributed in breast milk, contraindicated by some sources (AAP Committee states compatible w/ nursing ; AAFP states safe for nursing) _ Side Effect Mild leukopenia, lupus-like syndrome, cutaneous vasculitis, thrombocytopenia. Skin rash, urticaria, arthralgia and fever. GI discomfort, vomiting, headache. Potentially Fatal: Agranulocytosis, aplastic anaemia, liver injury and liver failure. _ Interaction May potentiate activity of anticoagulants. Doses of β-blockers, digitalis glycosides and theophylline may need to be reduced when patient becomes euthyroid.