Ticoplan 400

Introduction
Ticoplan 400 is an antibiotic used in the treatment of severe bacterial infections in hospitalized patients. It is effective against infections of the respiratory tract (eg. pneumonia), urinary tract, skin and soft tissues, bones and joints, heart, blood and others. Ticoplan 400 works by stopping the growth of bacteria and is useful for treating adults as well as children. It is a narrow-spectrum antibiotic that only covers the gram-positive type of bacteria. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. It may also be combined with other antibiotics to treat additional types of bacteria. Some people may develop local injection site reactions like pain, swelling, redness. However, this is usually minor and temporary. Other side effects like fever, itching and skin rash may be seen occasionally. Monitoring with regular kidney function tests may be needed while you are being treated with this medication. Inform your doctor if you have a history of an allergic reaction to this medication in the past. Use caution while driving or doing anything that requires concentration as it may cause dizziness and headaches. Consult your doctor if you are pregnant or breastfeeding before taking this medicine.

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Uses of Ticoplan 400
Severe bacterial infections
Side effects of Ticoplan 400
Common
Injection site reactions (pain, swelling, redness)
Fever
Itching
Skin rash
How to use Ticoplan 400
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Ticoplan 400 works
Ticoplan 400 is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Quick Tips
Ticoplan 400 is used for treating serious bacterial infections, which cannot be treated with other antibiotics like penicillins and cephalosporins.
Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
It is given by an injection or drip into a vein or into a muscle.
Use caution while driving or doing anything that requires concentration as it can cause dizziness and headaches.
Do not take Ticoplan 400 if you are pregnant or breastfeeding.
Brief Description
Indication
Gram-positive infection, CAPD-associated peritonitis
Adult Dose
Parenteral Severe Gram-positive infections Adult: Initially, 6 mg/kg on first day, followed by 3 mg/kg/day. Severe infection: 6 mg/kg every 12 hr for the 1st 3 doses followed by 6 mg/kg/day. Doses may be given via IM inj, IV bolus or IV infusion over 30 minutes. Intravenous Prophylaxis of Gram-positive infection in high-risk patients undergoing surgery Adult: 400 mg as single dose at induction of anesth. Continuous ambulatory peritoneal dialysis (CAPD)-associated peritonitis Adult: If the patient is febrile, an initial loading dose of 400 mg may be given. Teicoplanin is added to the dialysis solution at a concentration of 20 mg/litre; dose is added into each bag of solution in the first wk, followed by alternate bags in the second wk and then in the overnight dwell bag in the third wk.

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Child Dose
Parenteral Severe Gram-positive infections Child: Loading dose: 10 mg/kg every 12 hr for 3 doses followed by 6-10 mg/kg/day depending on severity of the infection. Neonates: Loading dose: 16 mg/kg on the 1st day, followed by maintenance doses of 8 mg/kg/day by IV infusion.

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Renal Dose
Parenteral Renal impairment: Usual dose to be given for first 3 days, thereafter adjust dose according to CrCl. CrCl (ml/min) Dosage Recommendation 40-60 1/2 initial dose given daily or initial dose every 2 days. <40 1/3 initial dose given daily or initial dose every 3 days. Intravenous Renal impairment: Dose adjustment may be required. _ Contraindication Hypersensitivity. Mode of Action Glycopeptide antibiotic with spectrum of activity is similar to vancomycin but teicoplanin may be more active in vitro against enterococci and some anaerobic organisms but some coagulase-negative Staphylococci are less sensitive to teicoplanin than to vancomycin. Precaution Preexisting renal insufficiency, hypersensitivity to vancomycin. Perform periodic haematological studies, renal, LFT. Pregnancy, lactation. Side Effect Fever, chills, allergic reactions, GI disturbances, headache, dizziness, "red-man" syndrome, disturbances in liver enzymes, renal impairment, ototoxicity, blood dyscrasias. Pain, erythema, thrombophloebitis, abscess at site of admin. Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis. _ Interaction Other nephrotoxic and/or neurotoxic drugs.