Ufol

Introduction
Ufol is a general anesthetic. It is used in major surgical procedures. It allows the procedures to be carried out without pain and distress. This injection is used in a hospital setting only. Ufol is used in general anesthesia. It causes loss of consciousness which is reversible. It is administered under the supervision of a healthcare professional. The most common side effects include headache, vomiting, and nausea. This Ufol is safe to use in pregnancy, breastfeeding mothers, patients of liver and kidney disease. Inform your doctor if you are on any medications or have any known allergy to this medicine before the start of the procedure. It is not advised to consume alcohol after you have been administered. Driving should not be done as this medicine may cause sleepiness and may impair your ability to think or react. It is also advised not to operate machinery because of these effects.

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Uses of Ufol
General Anaesthesia
Side effects of Ufol
Common
Nausea
Headache
Vomiting
Local site pain
Slow heart rate
Decreased blood pressure
How to use Ufol
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
How Ufol works
Ufol is a general anaesthetic. It works by causing reversible loss of consciousness. This allows surgical procedures to be carried out without pain and distress.
Quick Tips
Ufol helps induce unconsciousness (sleep) so that surgical operations or other procedures can be performed.
It is given to you as an injection by your doctor.
After use, you may still feel sleepy for some time. Do not drive or do anything that requires focus until you are sure the effects have subsided.
Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
General anaesthesia, Sedation
Adult Dose
Intravenous Induction and maintenance of general anaesthesia Adult: Induction: 40 mg by inj or infusion every 10 sec. Usual dose: 1.5-2.5 mg/kg. Maintenance: 4-12 mg/kg/hr or intermittent bolus inj of 20-50 mg. Elderly: Including neurosurgical and debilitated patients: Infuse at a rate of 20 mg every 10 sec. Maintenance: 3-6 mg/kg/hr. Usual dose needed: 1-1.5 mg/kg. Sedation Adult: In diagnostic and surgical procedures: Initially, 6-9 mg/kg/hr by infusion given for 3-5 minutes or an alternative dose of 0.5-1 mg/kg by slow inj over 1-5 minutes. Maintenance: 1.5-4.5 mg/kg/hr infusion. Reduce maintenance dose by 20% for high-risk patients needing sedation. For ventilated patients: 0.3-4 mg/kg/hr by infusion. Monitor lipid concentrations if duration of sedation lasts >3 days.

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Child Dose
Intravenous Anesthesia Induction 3-16 years: 2.5-3.5 mg/kg IVP over 20-30 sec Maintenance 2 months to 16 years: 0.125-0.3 mg/kg/min IV

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Contraindication
Electroconvulsive therapy, obstetrics. Sedation in children <16 yr. Pregnancy, lactation. _ Mode of Action Short-acting, lipophilic sedative/hypnotic; causes global CNS depression, presumably through agonist actions on GABAa receptors. Precaution Paediatrics, elderly, hypovolaemia, epilepsy, lipid disorders, patients with increased intracranial pressure. Avoid rapid bolus doses in high risk patients. Emulsion formulation of propofol 2% should only be used in children >3 yr. Lactation: Excreted in breast milk; effect on nursing infant not known

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Side Effect
>10% Hypotension (peds 17%; adults 3-26%),Apnea lasting 30-60 sec (peds 10%; adults 24%),Apnea lasting >60 sec (peds 5%; adults 12%),Movement (peds 17%; adults 3-10%),Injection site burning/stinging/pain (peds 10%; adults 18%) 1-10% Respiratory acidosis during weaning (3-10%),Hypertriglyceridemia (3-10%),Hypertension (peds 8%),Rash (peds 5%; adults 1-3%),Pruritus (1-3%),Arrhythmia (1-3%),Bradycardia (1-3%),Cardiac output decreased (1-3%; concurrent opioid use increases incidence).Tachycardia (1-3%) <1% Arterial hypotension,Anaphylaxis,Asystole,Bronchospasm,Cardiac arrest,Seizures,Opisthotic rxn,Pancreatitis,Pulmonary edema,Phlebitis,Thrombosis,Renal tubular toxicity Potentially Fatal: Apnoea, bradycardia, hypotension, convulsions; anaphylaxis. _ Interaction Reduce dose if given with nitrous oxide or halogenated anaesthetics. Increased sedative, anaesthetic and cardiorespiratory effects when used with other CNS depressants.