Medicine Overview of Vonocab Trio 20mg+500mg+500mg tablet
Dosage
The recommended dosage regimen is- Vonoprazan 20 mg Amoxicillin 1000 mg Clarithromycin 500 mg Each given twice daily (morning and evening, 12 hours apart), with or without food, for 14 days. Geriatrics: The standard triple therapy regimen increased risk of torsade de pointes due to the clarithromycin component. Renal Impairment: Avoid use in severe renal impairment. Hepatic Impairment: Avoid use in moderate and severe hepatic impairment. Take medicine as per doctor’s advice.
Interaction
Triple therapy regimen should be used with caution when co-administrated with following drugs: Tacrolimus, cyclosporine, clopidogrel, citalopram, cilostazol, probenecid, allopurinol, itraconazole, ketoconazole, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, saquinavir, ritonavir, etravirine, rilpivirine-containing products, atazanavir, nelfinavir.
Contraindications
The standard triple therapy regimen is contraindicated in patients with known hypersensitivity to vonoprazan, amoxicillin or any other betalactams, clarithromycin or any other macrolide antimicrobials
Side Effects
Side Effects
Precautions
Hypersensitivity Reactions: Serious and occasionally fatal reactions (e.g., anaphylaxis) have been reported with components of this triple pack. If hypersensitivity reactions occur, discontinue and institute immediate therapy (e.g., anaphylaxis management). Severe Cutaneous Adverse Reactions (SCAR): Discontinue this pack at the first signs or symptoms of SCAR or other signs of hypersensitivity and consider further evaluation. Clostridioides difficile-associated diarrhea (CDAD): Evaluate if diarrhea occurs with this pack and Due to the Clarithromycin Component: QT Prolongation: Avoid this pack in patients with known QT prolongation or receiving drugs known to prolong the QT interval, ventricular arrhythmia (torsades de pointes), hypokalemia/hypomagnesemia, significant bradycardia,
Overdose Effects
If overdose occurs, should consult with doctor immediately.
Storage Conditions
Do not store above 30°C. Keep in a dry place. Protect from light and keep out of the reach of children.
Brief Description
Indications
The standard triple therapy regimen is indicated in the eradication of H. pylori in active chronic gastritis, duodenal and gastric ulcers.
Pharmacology
Helicobacter pylori (H. pylori) is implicated in the etiology of gastritis & peptic ulcer. The standard triple therapy regimen contains 20 mg vonoprazan tablet, 500 mg amoxicillin capsule and 500 mg clarithromycin tablet for oral administration is effective for eradicating H. pylori. Vonoprazan suppresses basal and stimulated gastric acid secretion at the secretory surface of the gastric parietal cell through inhibition of the H+ K+ -ATPase enzyme system in a potassium competitive manner. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, vonoprazan has been characterized as a type of gastric proton-pump inhibitor, in that
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