Xolamid T OSD 5ml

Introduction
Xolamid T OSD 5ml is a prescription medicine having a combination of medicines that is used to treat pressure in the eyes (ocular hypertension) and glaucoma. It works by decreasing the pressure of fluid in the eye (aqueous humor), which helps in lowering the increased eye pressure. Xolamid T OSD 5ml is to be used only in the affected eye in the dose and duration as advised by the doctor. Wash your hands before using this medicine. It is advised to check the label for directions before use. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. The most common side effects include irritation and burning sensation at the application site. If these side effects persist for a longer duration, inform your doctor. In case by accident, this medicine goes into your ears, nose or mouth, immediately rinse it with water. Inform your doctor if you are pregnant or breastfeeding or are allergic to this medicine or taking any other medication. It is advised not to drive or operate heavy machinery after use of this medicine as it may cause blurring of vision and may affect your ability to drive.

_
Uses of Xolamid T OSD 5ml
Ocular hypertension
Glaucoma
Side effects of Xolamid T OSD 5ml
Common
Itching
Irritation
Stinging sensation
Burning sensation in eye
Blurred vision
Eye redness
Taste change
How to use Xolamid T OSD 5ml
This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.
How Xolamid T OSD 5ml works
Xolamid T OSD 5ml is a combination of two medicines: Brinzolamide and Timolol. Brinzolamide is a carbonic anhydrase inhibitor while Timolol is a beta blocker. They work by decreasing the production of aqueous humour (fluid in the eye), thereby lowering the increased eye pressure.
Quick Tips
Xolamid T OSD 5ml is a combination of two medicines that lowers high pressure in the eye and reduces the risk of vision loss.
Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the drop.
If you wear soft contact lenses, remove them before putting in these eye drops and wait at least 15 minutes before putting your lenses back in.
Do not touch the tip of the dropper to any surface, or to your eye, to avoid contaminating the eye drops.
Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
It may cause short term blurring of vision when first used. Use caution before driving or using machines.
It may cause temporary burning or itching sensation in the eye. Inform your doctor if this does not go away.
Make sure to use within 4 weeks of opening the bottle.
Brief Description
Indication
Treatment of elevated IOP in, open-angle glaucoma, ocular HTN
Adult Dose
1 drop into the affected eye(s) twice daily.
Contraindication
Bronchial asthma, severe COPD, sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock, severe allergic rhinitis, bronchial hyperreactivity, hyperchloraemic acidosis, severe renal impairment.
Mode of Action
Brinzolamide is a carbonic anhydrase inhibitor that decreases secretion of aqueous humor thus reducing intraocular pressure. Exact mechanism of ocular hypotensive effect is unclear, but it is thought to be related to reduction of aqueous humour formation. beta-blockade also causes lowering of BP.

_
Precaution
Control cardiac failure prior to therapy. History of severe cardiac & resp disease. Patients subject to hypoglycemia or labile insulin-dependent diabetes. May mask hyperthyroidism or worsen Prinzmetal’s angina, severe peripheral & central circulatory disorders & hypotension. History of atopy or severe anaphylactic reaction to a variety of allergens. Avoid concomitant use of 2 local beta-adrenergic blockers or 2 local carbonic anhydrase inhibitors. Close monitoring of IOP in patients w/ pseudoexfoliative or pigmentary glaucoma. Narrow-angle glaucoma. Monitor patients w/ compromised corneas eg patients w/ DM or corneal dystrophies. Remove contact lenses prior to application; reinsert after 15 min. May impair ability to drive or operate machinery. Pregnancy. Childn <18 yr. _ Side Effect Dysgeusia, blurred vision, eye pain & irritation, foreign body sensation. _ Interaction Brinzolamide: Concurrent use w/ oral carbonic anhydrase inhibitors may lead to additive systemic effects. Concurrent use w/ high-dose salicylates may lead to toxicity. Timolol: Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive effects w/ other antihypertensives (e.g. hydralazine, methyldopa). Increased ?-adrenergic blockade (e.g. decreased heart rate) w/ quinidine. Rebound HTN due to abrupt withdrawal of clonidine. Hypotensive effect may be antagonised by NSAIDs (e.g. indomethacin, ibuprofen). _