Y 45

Introduction
Y 45 is a medicine used in the treatment of male hypogonadism caused due to low testosterone levels. It is only prescribed to the men with known medical conditions. It helps in restoring the level of testosterone in the male body. Y 45 is injected directly into the skin or muscles under the medical supervision of a doctor. It should be taken as your doctor’s advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include acne, breast enlargement, deepening of voice and Injection site reactions (pain, swelling, redness). If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some side effects may mean you should stop taking this medicine shortness of breath, frequent or persistent erections, and low sperm count. Before taking this medicine, tell your doctor if you have ever had high blood pressure, heart attack, and stroke. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Your doctor might perform regular blood tests to keep track of testosterone, and prostate specific antigen (PSA) levels.

_
Uses of Y 45
Male hypogonadism
Side effects of Y 45
Common
Injection site reactions (pain, swelling, redness)
Absence of menstrual periods
Tiredness
Joint pain
Back pain
How to use Y 45
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Y 45 works
Y 45 is similar to the natural male hormone, testosterone. It works by replenishing the deficient testosterone levels in adult men. Lack of testosterone may cause various health problems including impotence, infertility, low sex drive, tiredness, depressive mood and bone loss.
Quick Tips
You have been prescribed Y 45 for the treatment of low testosterone levels.
Your doctor will administer this injection into a muscle or skin.
Your doctor may monitor you for 30 minutes after your shot to make sure you do not develop breathing problems or get a severe allergic reaction due to the medicine.
Your doctor may get your blood tests done regularly to monitor red blood cells, liver function, testosterone, and prostate specific antigen (PSA) levels while taking Y 45.
Inform your doctor if you experience symptoms such as frequent or persistent erections, irritability, nervousness or weight gain after starting treatment with this medicine.
Brief Description
Indication
Hypogonadism, Testosterone replacement therapy
Administration
Applying the gel to skin of lower abdomen, inner thighs or shoulders and upper arms, usually once daily.
Adult Dose
Topical Adult: Testosterone gels: 50 mg/day initially, applied topically to shoulders, upper arms, or abdomen (not to genitals) each morning; titrated according to predose serum testosterone levels (25 mg/2.5 g, 50 mg/5 g); not to exceed 100 mg/day

_
Child Dose
Safety and efficacy not established
Contraindication
Hypercalcaemia or hypercalciuria, males with breast or prostate carcinoma. Pregnancy and lactation.
Mode of Action
Testosterone is the principal endogenous androgen responsible for promoting the growth and development of male sexual organs and maintaining secondary sex characteristics in androgen-deficient males.
Precaution
Cardiovascular disorders, skeletal metastases, renal or hepatic impairment, epilepsy, migraine, diabetes or other conditions which may be aggravated by fluid retention, eg heart failure. Elderly, prepubertal boys. Monitor signs of virilization (females) and development of priapism or excessive sexual stimulation (males). Periodic haemoglobin, lipid determinations and rectal prostate examination. Lactation: Drug is excreted into breast milk; use is contraindicated

_
Side Effect
>10% Pruritus at application site (37%),Skin reactions at application site (16.1%),Blisters under skin (12%) 1-10% Erythema at application site (7%),Vesicles at application site (6%),Allergic contact dermatitis (4%),Burning at application site (3%),Induration at application site (3%) Frequency Not Defined Abnormal dreams,Acne,Anaphylaxis,Bladder irritability,Breast soreness,Cholestatic jaundice,Deep vein thrombosis, Dry skin,Fatigue,Gynecomastia,Headache,Insomnia,Menstrual irregularities,Priapism,Suppression of factors II, V, VII,Virilization

_
Interaction
Enhance activities of ciclosporine, antidiabetics, thyroxine, anticoagulants. Long term use of testosterone may cause resistance to effects of neuromuscular blockers. Enhance fluid retention from corticosteroids.