Zimon Plus

Indication
Iron deficiency anemia, Megaloblastic anemias
Adult Dose
Adults: 1-2 capsules daily.
Child Dose
Child: 1 capsule daily.
Contraindication
Hypersensitivity to folic acid, cyanocobalamin, pyridoxine, or any component of the formulation
Mode of Action
Vitamin B12 (cyanocobalamin): Required for the maintenance of normal erthropoiesis, nucleprotein and myelin synthesis, cell reproduction and normal growth; Coenzyme; metabolic functions include protein synthesis and carbohydrate metabolism. Plays role in cell replication and hematopoiesis. Iron: Essential component in the formation of hemoglobin; adequate amounts of iron are necessary for effective erythropoiesis; also serves as a cofactor of several essential enzymes, including cytochromes that are involved in electron transport. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin. Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy.

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Precaution
Iron chelates with antacid and tetra cycline, so there absorption may be impaired if use concurrently.
Side Effect
Iron: Constipation, diarrhea, nausea, vomiting, dark stools, and abdominal pain Folic acid: Allergic sensitization Bronchospasm,Flushing,Malaise,Erythema,Rash,Diarrhea,Nausea,Pruritus,Urticaria

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Interaction
Cyanocobalamin: Absorption reduced by antibiotics, aminosalicylic acid, anticonvulsants, biguanides, cholestyramine, cimetidine, colchicine, K salts, methyldopa. Elemental iron: Antacids may decrease the absorption of carbonyl iron. Folic acid: Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations.

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