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Zocil 100

Name: Zocil 100
SKU: SKU-oymIiO3T
Availability: InStock

Tablet - 100mg

Beximco Pharmaceuticals Ltd.

Generic: Cilostazol

1 Tablet

Original price was: Tk. 12.Current price is: Tk. 11.

Description

Medicine Overview of Zocil 100mg Tablet

Introduction

Zocil 100 is used in the treatment of pain in legs due to insufficient blood flow (intermittent claudication). It also helps in reducing cramping, numbness, or weakness in the legs that occurs on walking in such patients.

Zocil 100 should be taken regularly as advised by the doctor. You should take it on an empty stomach and at a fixed time. This medicine should not be stopped abruptly without consulting the doctor.

It may cause side effects like headache, edema, nausea, diarrhea, dizziness and chest pain. Use of this medicine may increase your risk of bleeding. Let your doctor know immediately if you see pinpoint rash or blood in your vomits, urine, or stool.

This medicine may not be suitable for some people. You must inform the doctor if you are suffering from any liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it.

Uses of Zocil 100

Intermittent claudication

Side effects of Zocil 100

Common

Headache
Palpitations
Abnormal stool
Diarrhea
Dizziness
Chest pain
Loss of appetite
Bleeding
Rash

How to use Zocil 100

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zocil 100 is to be taken empty stomach.

How Zocil 100 works

Zocil 100 widens the blood vessels and decreases the stickiness of the platelets, thereby increasing the blood flow to the lower limbs.

What if you forget to take Zocil 100?

If you miss a dose of Zocil 100, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

Take it at least half an hour before or two hours after breakfast and dinner.

It may take up to 12 weeks before your symptoms improve. Keep using the medication as directed.

Consult your doctor, if your symptoms do not improve after 4 weeks of treatment.

It may cause dizziness. Don’t drive or do anything that requires mental focus until you know how it affects you.

Do not take it if you have heart failure, persistent chest pain at rest, or have had a heart attack or any heart surgery in the last six months.

Brief Description

Indication

Peripheral vascular disease, Intermittent claudication

Administration

Should be taken on an empty stomach. Take at least ½ hr before or 2 hr after meals.

Adult Dose

Oral
Peripheral vascular disease
Adult: 100 mg bid.
May reduce dose in patients taking enzyme inhibitors concurrently.

Hepatic Impairment
Moderate to severe: Use caution

Renal Dose

Renal Impairment
CrCl< 25 mL/min: Use caution

Contraindication

Heart failure; known predisposition to bleeding; history of ventricular arrhythmias; QT interval prolongation; severe renal impairment; moderate to severe hepatic impairment.

Mode of Action

Cilostazol is a reversible, selective inhibitor of phosphodiesterase-III (PDE-III), thereby suppressing cyclic adenosine monophosphate (cAMP) degradation. Increase in cAMP in platelets and blood vessels leads to inhibition of platelet aggregation and vasodilation. Cilostazol also inhibits adenosine uptake into cells, which augments the cAMP-elevating effect of PDE-III inhibition.

Precaution

Congestive heart disease. Concurrent therapy with clopidogrel has not been studied for safety or efficacy. Pregnancy and lactation.

Lactation: Excretion in milk unknown; not recommended

Side Effect

>10%
Headache (27-34%),Diarrhea (12-19%),Abnormal stools (12-15%),Infection (10-14%),Rhinitis (7-12%),Pharyngitis (7-10%)

1-10%
Dizziness (9-10%),Palpitations (5-10%),Peripheral edema (7-9%),Back pain (6-7%),Dyspepsia (6%),Abdominal pain (4-5%),Tachycardia (4%),Increased cough (3-4%),Myalgia (2-3%),Atrial fibrillation (<2%),CHF (<2%),MI (<2%),Hematemesis (<2%),Ecchymosis (<2%),Blood in eye (<2%),Epistaxis (<2%),Hemoptysis (<2%),Nausea

Frequency Not Defined
Decreased platelet aggregation,Agranulocytosis,Aplastic anemia,Leukopenia,Thrombocytopenia,Stevens-Johnson syndrome

Pregnancy Category Note

Pregnancy category: C

Lactation: Excretion in milk unknown; not recommended

Interaction

Co-admin with drugs that affect CYP3A4 (erythromycin, other macrolides, diltiazem) or CYP2C19 (omeprazole) may influence the pharmacokinetics of cilostazol.