Medicine Overview of Aminophylline 100mg Tablet
Aminophylline is used to treat and prevent symptoms of asthma and chronic obstructive pulmonary disorder (a lung disorder in which flow of air to the lung is blocked). It helps in relaxing the muscles of the air passages, thus widening it and making it easier to breathe.
Aminophylline can be taken with the food in evening. But take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Do not miss even a single dose, if in any case, you missed a dose, take it as soon as you remember or better to skip the missed dose and continue with regular dosing. It does not work immediately or prevent the already started breathing trouble, hence always carry your medical inhaler with you for an emergency.
The most common side effects of this medicine include headache, insomnia (difficulty sleeping), vomiting, and nausea. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Generally, it is advised not to consume alcohol or do not smoke while on treatment. You must avoid high caffeinated products like coffee, tea, and dark chocolates as it enhances drug side effects.
Before taking this medicine, let your doctor if you have kidney or liver disease or if you have heart-related problems. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant or breastfeeding before starting the treatment.
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Headache
- Insomnia (difficulty in sleeping)
- Vomiting
- Nausea
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You have been prescribed Aminophylline for prevention and treatment of asthma and chronic obstructive pulmonary disease (COPD).
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It should be taken at the same time each day, preferably in the evening after food.
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It does not work right away and should not be used to relieve sudden breathing problems. Always keep a fast-acting (rescue) inhaler with you.
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Your doctor may take regular blood test to monitor potassium level and the level of this medicine in your body.
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Notify your doctor if you have ever been diagnosed with kidney, liver or heart disease, or if you have a smoking history. Your dose may need to be adjusted.
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Do not discontinue use without consulting your doctor, even if you feel better.
Oral
Chronic bronchospasm
Adult: As hydrate: Initially, 225-450 mg bid, increased if necessary.
Intravenous
Acute severe bronchospasm
Adult: Loading dose: 5 mg/kg (ideal body weight) or 250-500 mg (25 mg/ml) by slow inj or infusion over 20-30 min. Maintenance infusion dose: 0.5 mg/kg/hr. Max rate: 25 mg/min.
Elderly: Dose reduction may be ncessary.
Hepatic impairment: Dose reduction may be ncessary.
Other xanthines. Clearance reduced by allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon-alpha, macrolide antibiotics, quinolones, oral contraceptives, thiabendazole and viloxazine. Clearance increased by phenytoin, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, cigarette smoking. Corticosteroids, diuretics, beta2-agonists.
Potentially Fatal: Increased risk of cardiac arrhythmias with sympathomimetics and halothane. Tachycardia with pancuronium. beta-blockers inhibit metabolism. Increased risk of convulsion with quinolones, ketamine.
Oral
Chronic bronchospasm
Child: >3 yr: As modified-release hydrate: 12 mg/kg daily increased to 24 mg/kg daily in 2 divided doses after 1 wk.
Intravenous
Acute severe bronchospasm
Child: Loading dose: same as adult dose. Maintenance dose: 6 mth-9 yr: 1 mg/kg/hr and 10-16 yr: 0.8 mg/kg/hr.
Nausea, vomiting, abdominal pain, diarrhoea, headache, insomnia, dizziness, anxiety, restlessness; tremor, palpitations.
Potentially Fatal: Convulsions, cardiac arrhythmias, hypotension and sudden death after too rapid IV injection.
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