Buticef 400

Introduction
Buticef 400 is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (eg. pneumonia), urinary tract, ear, nasal sinus, and throat. It kills bacteria, which helps to improve your symptoms and cure the infection. Buticef 400 may be taken with or without food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back. It will not work for viral infections such as flu or the common cold. Using any antibiotic when you do not need it can make it less effective for future infections. The most common side effects of this medicine include vomiting, allergic reaction, stomach pain and diarrhea. Taking this medicine along with some food may help to prevent indigestion and upset stomach. Seek emergency medical help if you get a rash, itchy skin, swelling of face and mouth, or have difficulty breathing. Before using it, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. Pregnant and breastfeeding mothers should consult their doctor before using it.

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Uses of Buticef 400
Bacterial infections
Side effects of Buticef 400
Common
Allergic reaction
Stomach pain
Diarrhea
How to use Buticef 400
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Buticef 400 may be taken with or without food, but it is better to take it at a fixed time.
How Buticef 400 works
Buticef 400 is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Buticef 400?
If you miss a dose of Buticef 400, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
Your doctor has prescribed Buticef 400 to cure your infection and improve your symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
Discontinue Buticef 400 and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
Take it with food to avoid an upset stomach.
Avoid consuming alcohol while taking Buticef 400 as it may cause increased side effects.
Brief Description
Indication
Respiratory tract infections, Urinary tract infections
Administration
Susp: Should be taken on an empty stomach. Take 2 hr before or 1 hr after meals. Cap: May be taken with or without food.

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Adult Dose
Oral Respiratory tract infections, Urinary tract infections Adult: 400 mg once daily for 10 days.

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Child Dose
Child: <6 months: Safety and efficacy not established 6-12 years old or <45 kg: 9 mg/kg PO qDay; 400 mg/day PO for 10 days maximum >12 years old or >45 kg: As in adults

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Renal Dose
Renal impairment: CrCl (ml/min) 30-49 200 mg once daily. 5-29 100 mg once daily.

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Contraindication
Hypersensitivity to cephalosporins.
Mode of Action
Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many beta-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.
Precaution
Hypersensitivity to penicillins; renal impairment; Porphyria. Monitor renal and haematologic status. Lactation: excretion in milk unknown; use with caution

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Side Effect
1-10% Increased BUN (4%),Nausea (4%),Diarrhea (3%),Headache (3%),Increased eosinophils (3%),Decreased hemoglobin (2%),Dyspepsia (2%),Thrombocytosis (2%),Abdominal pain (1%),Dizziness (1%),Increased ALT (1%),Increased bilirubin (1%),Vomiting (1%) <1% Anorexia,Candidiasis,Constipation,Dysuria,Agitation,Fatigue,Insomnia,Irritability,Paresthesia,Rigors,Diaper rash,Urticaria,Dry mouth,Dyspnea,Nasal congestion,Increased transaminases,Increased creatinine,Leukopenia Potentially Fatal: Pseudomembranous colitis. _ Pregnancy Category Note Pregnancy Category: B Lactation: excretion in milk unknown; use with caution _ Interaction Enhanced nephrotoxicity of aminoglycosides. Increased serum concentration w/ probenecid. Decreased serum concentration w/ zinc salts.