Medicine Overview of Orbuten 400mg Capsule
Introduction
Orbuten 400 is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (eg. pneumonia), urinary tract, ear, nasal sinus, and throat. It kills bacteria, which helps to improve your symptoms and cure the infection. Orbuten 400 may be taken with or without food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should
Uses of Orbuten 400
- Bacterial infections
Side effects of Orbuten 400
Common
- Allergic reaction
- Stomach pain
- Diarrhea
How to use Orbuten 400
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Orbuten 400 may be taken with or without food, but it is better to take it at a fixed time.
How Orbuten 400 works
Orbuten 400 is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Orbuten 400?
If you miss a dose of Orbuten 400, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
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Your doctor has prescribed Orbuten 400 to cure your infection and improve your symptoms.
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Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
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Discontinue Orbuten 400 and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
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Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
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Take it with food to avoid an upset stomach.
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Avoid consuming alcohol while taking Orbuten 400 as it may cause increased side effects.
Brief Description
Indication
Respiratory tract infections, Urinary tract infections
Administration
Susp: Should be taken on an empty stomach. Take 2 hr before or 1 hr after meals.
Cap: May be taken with or without food.
Cap: May be taken with or without food.
Adult Dose
Oral
Respiratory tract infections, Urinary tract infections
Adult: 400 mg once daily for 10 days.
Respiratory tract infections, Urinary tract infections
Adult: 400 mg once daily for 10 days.
Child Dose
Child:
<6 months: Safety and efficacy not established
<6 months: Safety and efficacy not established
6-12 years old or <45 kg: 9 mg/kg PO qDay; 400 mg/day PO for 10 days maximum
>12 years old or >45 kg: As in adults
Renal Dose
Renal impairment:
CrCl (ml/min)
30-49 200 mg once daily.
5-29 100 mg once daily.
CrCl (ml/min)
30-49 200 mg once daily.
5-29 100 mg once daily.
Contraindication
Hypersensitivity to cephalosporins.
Mode of Action
Ceftibuten inhibits bacterial cell wall synthesis. It is stable to hydrolysis by many beta-lactamases and has greater activity than 1st or 2nd generation cephalosporins against gm-ve bacteria. It is less active in vitro than cefexime against S. pneumoniae.
Precaution
Hypersensitivity to penicillins; renal impairment; Porphyria. Monitor renal and haematologic status.
Lactation: excretion in milk unknown; use with caution
Lactation: excretion in milk unknown; use with caution
Side Effect
1-10%
Increased BUN (4%),Nausea (4%),Diarrhea (3%),Headache (3%),Increased eosinophils (3%),Decreased hemoglobin (2%),Dyspepsia (2%),Thrombocytosis (2%),Abdominal pain (1%),Dizziness (1%),Increased ALT (1%),Increased bilirubin (1%),Vomiting (1%)
Increased BUN (4%),Nausea (4%),Diarrhea (3%),Headache (3%),Increased eosinophils (3%),Decreased hemoglobin (2%),Dyspepsia (2%),Thrombocytosis (2%),Abdominal pain (1%),Dizziness (1%),Increased ALT (1%),Increased bilirubin (1%),Vomiting (1%)
<1%
Anorexia,Candidiasis,Constipation,Dysuria,Agitation,Fatigue,Insomnia,Irritability,Paresthesia,Rigors,Diaper rash,Urticaria,Dry mouth,Dyspnea,Nasal congestion,Increased transaminases,Increased creatinine,Leukopenia
Potentially Fatal: Pseudomembranous colitis.
Pregnancy Category Note
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Interaction
Enhanced nephrotoxicity of aminoglycosides. Increased serum concentration w/ probenecid. Decreased serum concentration w/ zinc salts.
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