Medicine Overview of Carnovas HZ 5/12.5mg/12.5mg Tablet
Carnovas HZ 5/12.5 is a combination medicine used for treating hypertension (high blood pressure). By lowering the blood pressure, it helps in preventing future heart attack and stroke.
Carnovas HZ 5/12.5 should be taken with or without food preferably in the morning to avoid frequent urination at night. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition may get worse. Keeping active with regular exercise, reducing your weight and eating a healthy diet will also help control your blood pressure. Follow your doctor’s advice while taking this medicine.
Nausea, constipation, fatigue, headache, and shortness of breath are some common side effects of this medicine. Consult your doctor If any of these bother you, or get worse, or do not go away. Drink plenty of fluids while taking medicine to overcome muscle weakness, dry mouth, and extreme thirst. Dizziness or headache may occur due to low blood pressure, hence rise slowly from sitting position or avoid driving.
Before taking it, let your doctor know if you have any liver or kidney problems. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You also need to tell your doctor what other medicines you are taking especially those used to treat high blood pressure or heart conditions. You should have your blood pressure, kidney function, blood sugar level and the levels of salts such as potassium or magnesium checked regularly to make sure that this medicine is working properly.
- Hypertension (high blood pressure)
- Nausea
- Constipation
- Diarrhea
- Fatigue
- Dizziness
- Headache
- Increased blood uric acid
- Decreased potassium level in blood
- Glucose intolerance
- Altered blood lipid level
- Breathlessness
- Swelling of hands
- Feet swelling
- Paresthesia (tingling or pricking sensation)
- Decreased magnesium level in blood
- Increased calcium level in blood
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It is a combination of two blood pressure lowering medications used for the treatment of high blood pressure.
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It can be taken with or without food.
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Do not stop taking Carnovas HZ 5/12.5 suddenly as it can cause your blood pressure to rise suddenly thereby increasing the risk of heart attack and stroke.
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It may cause dizziness. If this happens to you, get up slowly when rising from a sitting or lying position.
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It can hide symptoms of low blood sugar if you’re diabetic. Monitor your blood sugar levels regularly.
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Carnovas HZ 5/12.5 may cause dehydration. Drink plenty of fluids and Inform your doctor if you develop extreme thirst, muscle weakness or very dry mouth.
Oral
Hypertension
Adult: Per tablet contains nebivolol 5 mg and hydrochlorothiazide 12.5 mg: 1 tablet once daily.
Nebivolol exerts its actions by exhibiting a high selectivity for beta-1 adrenergic receptors and also by reducing the peripheral vascular resistance by modulating nitrous oxide release.
Hydrochlorothiazide inhibits the reabsorption of Na and chloride at the beginning of distal convoluted tubule. It causes natriuretic effect mainly by decreasing Na and chloride reabsorption in the cortical segment of the ascending limb of the Loop of Henle by inhibition of a specific Na+Cl- co-transporter.
Nebivolol – Headache, fatigue, parasthesias, dizziness.
Hydrochlorothiazide – Hypotension including orthostatic hypotension, pancreatitis, intrahepatic cholestatic jaundice, diarrhoea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia, thrombocytopenia, photosensitivity, fever, urticaria, rash, purpura, hyperglycemia, glycosuria, hyperuricemia, restlessness, impotence.
Potentially Fatal: Seizures, may unmask diabetes mellitus. Hyponatraemia and idiosyncratic, hypersensitivity reactions.
Symptomatic hyponatraemia when combined with carbamazepine. Predisposes to allopurinol sensitivity reactions and impaired renal function. Potentiates hypotensive effect of beta blockers and ACE inhibitors; these also reduce diuretic-induced hypokalaemia.
Potentially Fatal: Enhance neuromuscular blocking action of competitive muscle relaxants. Cross-allergy with sulphonamides and sulphonylurea hypoglycaemics with resultant acute interstitial nephritis and vasculitis. Potentiates bone-marrow suppression caused by anticancer drugs. Potentiates aminoglycoside nephrotoxicity. Impaired control of diabetes by oral hypoglycaemic agents. May precipitate digitalis toxicity and lithium toxicity. Increased risk of hypokalaemia with corticosteroids. Prolongs paralysis caused by tubocurarine.
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