G-Thiazide T

Indication
Hypertension, Oedema
Administration
Should be taken with food. Take after meals.
Adult Dose
Hypertension 1-2 tablets/capsules (37.5-50 mg triamterene and 25 mg HCTZ) PO qDay 1 tablet (75 mg triamterene and 50 mg HCTZ) PO qDay Dosing considerations Monitor serum potassium Edema 1-2 tablets/capsules (37.5-50 mg triamterene and 25 mg HCTZ) PO qDay 1 tablet (75 mg triamterene and 50 mg HCTZ) PO qDay

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Child Dose
Safety and efficacy not established
Contraindication
severe renal or hepatic impairment, preexisting or drug-induced hyperkalemia, patients at risk of respiratory or metabolic acidosis. Lactation.
Mode of Action
Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions. Triamterene is a potassium sparing diuretic which appears to act mainly on the distal renal tubules. It increases the excretion of Na and reduces the excretion of potassium. It adds to the natriuretic but reduces the kaliuretic effects of other diuretics. It is structurally similar to folate and has anti-folate activity.

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Precaution
Renal and hepatic impairment; cirrhosis; DM; hyponatraemia; hyperuricaemia; history of nephrolithiasis; depleted folic acid stores. Monitor electrolyte concentrations closely, especially potassium levels. Observe for signs of liver damage, blood dyscrasias or other idiosyncratic reactions. Discontinue treatment if urinary calculus is passed. Pregnancy and elderly. Lactation: Not recommended; discontinue drug or do not nurse

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Side Effect
Triamterene Jaundice,Weaknes,Headache,Azotemia,Dizziness,Fatigue,Xerostomia,Photosensitivity,Rash,Diarrhea,Nausea,Vomiting,Hyperuricemia,Hyper/hypokalemia,Interstitial nephritis Hydrochlorothiazide Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Hypokalemia and/or hypomagnesemia,Hyperuricemia

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Interaction
May enhance toxicity of digitalis glycosides, neuromuscular-blocking action of competitive muscle relaxants, effect of antihypertensives. Increased risk of postural hypotension w/ alcohol, barbiturates, opioids. K-depleting effect enhanced by corticosteroids, lithium, ACTH, carbenoxolone.