Medicine Overview of Ketozol Shampoo 2% Shampoo
Introduction
Ketozol Shampoo belongs to a group of medicines called antifungals. It is used to treat fungal infections of the skin. It works by killing the fungus that causes infections such as athlete’s foot, thrush and ringworm. Ketozol Shampoo should be used in the dose and duration as prescribed by your doctor. This medicine should be used regularly to get the maximum benefit from it. Do not use more than you need, it will not clear your condition faster and may only increase the side effects. Skin infections will usually get better after 2 to 4 weeks. Do not use the
Uses of Ketozol Shampoo
- Fungal skin infections
Side effects of Ketozol Shampoo
Common
- Application site burning
- Skin peeling
How to use Ketozol Shampoo
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
How Ketozol Shampoo works
Ketozol Shampoo is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection.
What if you forget to take Ketozol Shampoo?
If you miss a dose of Ketozol Shampoo, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
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KZ Cream helps treat skin infections caused by many different types of fungi.
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Few healthy tips for Athlete’s Foot:
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Apply an amount sufficient to cover the affected area and 1 inch of the immediate surrounding skin.
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Finish the full course of treatment even if you feel better.
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Avoid getting it in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water.
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Inform your doctor if the infection has not cleared up after 4 weeks of treatment.
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Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Dandruff, Seborrheic dermatitis of the scalp, Pityriasis versicolor
Administration
To use the Ketoconazole shampoo, follow these steps: Use a small amount of water to wet the area where Ketoconazole shampoo is to be applied. Apply the shampoo to the affected skin/scalp and a large area around it. Use fingers to rub the shampoo until it forms lather. Leave the shampoo on skin/scalp for 5 minutes. Rinse the shampoo off skin/scalp with water.
Adult Dose
Seborrheic Dermatitis
Cream: Apply q12hr for 4 weeks or until clear
Shampoo: Apply twice weekly for 4 weeks, with at least 3 days between each shampoo
Cream: Apply q12hr for 4 weeks or until clear
Shampoo: Apply twice weekly for 4 weeks, with at least 3 days between each shampoo
Tinea Versicolor
Shampoo
Wet hair, massage into scalp for 1 min, and rinse
Repeat, leaving on scalp for 3 additional min
Shampoo twice weekly for 4 weeks, allowing 3 days between each shampoo
Tinea Corporis, Tinea Cruris, Tinea Pedis
Cream: Apply qDay for 2 weeks (6 weeks for tinea pedis), covering affected area
Child Dose
Seborrheic Dermatitis
<12 years: Safety and efficacy not established
<12 years: Safety and efficacy not established
>12 years (shampoo): Apply twice weekly for 4 weeks, with at least 3 days between each shampoo
>12 years (cream): Apply to affected area q12hr x4 weeks
Contraindication
Known hypersensitivity to ketoconazole or any of the excipients.
Mode of Action
Ketoconazole interferes w/ biosynthesis of triglycerides and phopholipids by blocking fungal CYP450, thus altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide.
Precaution
In patients who have been on prolonged treatment with topical corticosteroids, it is recommended that the steroid therapy be gradually withdrawn over a period of 2 to 3 weeks, while using Ketoconazole 2% shampoo to prevent any potential rebound effect. Avoid contact with the eyes. If the shampoo enters the eyes, rinse immediately with plenty of water.
Lactation: Not known if distributed into milk; use caution
Side Effect
1-10%
Irritation, severe,Pruritus,Stinging
Irritation, severe,Pruritus,Stinging
Frequency Not Defined
Shampoo
Hair loss/alopecia,Irritation,Abnormal hair texture,Scalp pustules,Dry skin,Pruritus,Oiliness/dryness of hair and scalp
Interaction
Reduced absorption w/ antimuscarinics, antacids, H2-blockers, PPIs, sucralfate. Reduced plasma concentrations w/ rifampicin, isoniazid, efavirenz, nevirapine, phenytoin. May also reduce concentrations of isoniazid and rifampicin. May reduce efficacy of oral contraceptives. May increase serum levels of CYP3A4 substrates e.g. digoxin, oral anticoagulants, sildenafil, tacrolimus. Potentially Fatal: May potentiate and prolong sedative and hypnotic effects of midazolam and triazolam. Increased plasma levels and prolonged QT intervals of astemizole, cisapride, dofetilide, pimozide, quinidine and terfenadine which may lead to torsade de pointes. Increased risk of myopathy w/ HMG-CoA reductase inhibitors (e.g. lovastatin, simvastatin). Markedly increased plasma levels of nisoldipine. Increased risk of
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