Medicine Overview of Litiam ER 400mg Tablet
Litiam ER is a prescription medicine used in the treatment of bipolar disorder and mania in adults. It is sometimes used to treat other behavioral disorders as well. It reduces the frequency of manic episodes and decreases the intensity of those episodes that might occur.
Litiam ER should be taken with food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Do not skip any doses and finish the full course of treatment even if you feel better. If you have missed a dose, take it as soon as you remember it. You should continue to take this medicine for as long as the doctor advises and do not stop taking it suddenly as it may result in harmful effects.
Side effects associated with the use of this medicine include tremor, slurred speech, uncoordinated body movements, nausea, acne, increased white blood cell count and memory impairment. It may also cause hair loss, enlarged thyroid gland, skin rash, and increased thirst. This medicine may also cause weight gain and to control it, you should have a balanced diet and exercise regularly. If you have been taking this medicine for a long time than regular monitoring of thyroid and kidney function may be required.
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- Mania
- Bipolar disoder
- Tremor
- Slurred speech
- Uncoordinated body movements
- Nausea
- Acne
- Increased white blood cell count
- Memory impairment
- Hair loss
- Goiter (enlarged thyroid gland)
- Skin rash
- Increased thirst
- Weight gain
- Polyuria
- Diarrhea
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Lithosun SR Tablet is one of the most effective long-term treatment for bipolar disorder.
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It may also be used for the treatment of mania.
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Your lithium blood levels, thyroid function, and kidney function may be monitored as long as you take this medicine.
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It may cause diarrhea and dehydration. Drink plenty of water and and use normal amounts of salt. Inform your doctor if you start or stop a low-salt diet.
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Monitor your weight during treatment as Lithosun SR Tablet can cause weight gain.
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Do not drive or do anything that requires mental focus until you know how it affects you.
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Inform your doctor if you have persistent stomach upset, problems with your speech, or extreme drowsiness. Your dose may need to be adjusted.
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Do not take Lithosun SR Tablet if you are pregnant or breastfeeding.
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Do not stop taking the medication suddenly without talking to your doctor.
Oral
Mania; Bipolar disorder; Recurrent unipolar depression
Adult: Treatment and prevention: Initially, 400-1,200 mg daily in 1-2 divided doses.
Serum lithium should be monitored 12 hours after dose, twice weekly until serum concentration and clinical condition stabilize, and every other month thereafter
Desirable range for serum lithium: 0.6-1.2 mEq/L; although higher serum concentrations may be needed, not to exceed 1.5 mEq/L
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Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-50 50-75% of normal dose.
<10 25-50% of normal dose.
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Decreased tolerance to lithium has been reported to ensue from protracted sweating or diarrhoea and, if such occur, supplemental fluid and salt should be administered under careful medical supervision and lithium intake reduced or suspended until the condition is resolved.
Lactation: Drug is excreted in breast milk; use not recommended
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>10%
Leukocytosis (most patients),Polyuria/polydypsia (30-50%),Dry mouth (20-50%),Hand tremor (45% initially, 10% after 1 year of treatment),Confusion (40%),Decreased memory (40%),Headache (40%),Muscle weakness (30% initially, 1% after 1 year of treatment),Electrocardiographic (ECG) changes (20-30%),Nausea, vomiting, diarrhea (10-30% initially, 1-10% after 1-2 years of treatment),Hyperreflexia (15%),Muscle twitch (15%),Vertigo (15%)
1-10%
Extrapyramidal symptoms, goiter (5%),Hypothyroidism (1-4%),Acne (1%),Hair thinning (1%)
Frequency Not Defined
Coma,Lethargy,Seizures,Renal toxicity
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Reduced serum levels with carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea. Enhanced hypothyroid effects with iodine salts. Enhanced effects of neuromuscular-blocking agents. Reduced pressor response to sympathomimetics.
Potentially Fatal: Increased risk of lithium toxicity with ACE inhibitors, angiotensin receptor antagonists, loop diuretics, metronidazole, phenytoin. Increased risk of neurotoxicity with carbamazepine, calcium-channel blockers, haloperidol, methyldopa, phenothiazines, SSRIs, TCAs. Increased serum levels with COX-2 inhibitors, NSAIDs (except sulindac, aspirin), tetracyclines, thiazide diuretics. Increased risk of encephalopathy with haloperidol. Increased risk of serotonin syndrome with sibutramine. Fatal malignant hyperpyrexia may occur when used with MAOIs.
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