Lizox 400

Name: Lizox 400
SKU: SKU-fwrIHU2r
Availability: InStock

Tablet - 400mg

Aristopharma Limited

Generic: Linezolid

10 Tablets (1 Box)

Original price was: Tk. 600.Current price is: Tk. 534.

Description

Medicine Overview of Lizox 400mg Tablet

Introduction

Lizox 400 is an antibiotic medicine used in the treatment of severe bacterial infections. It is used to treat infections of lungs (Pneumonia), skin and soft tissues. Lizox 400 may be taken with or without food, preferably at a fixed time. You should take it regularly as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. Do not stop taking it until you have finished the complete course, even when you feel better. If you stop taking this medicine too early then infection may return or

Uses of Lizox 400

Severe bacterial infections

Side effects of Lizox 400

Common

Vomiting
Headache
Nausea
Decreased blood cells (red cells, white cells, and platelets)
Diarrhea

How to use Lizox 400

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lizox 400 may be taken with or without food, but it is better to take it at a fixed time.
Avoid Lizox 400 with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Lizox 400 works

Lizox 400 is an antibiotic. It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.

Quick Tips

Lizox 400 treats serious infections caused by certain types of bacteria.

Take it with food to avoid an upset stomach.

Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.

Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn’t stop or if you find blood in your stools.

Avoid taking excessive cheese, processed meats, alcohol, or soy sauce while taking this medication as these may cause an excessive rise in your blood pressure.

Inform your doctor if you develop fever, shortness of breath, or any changes in your vision.

Do not take it for more than 14 days without consulting your doctor.

Brief Description

Indication

Community-acquired pneumonia, Skin and skin structure infections, Nosocomial pneumonia

Administration

May be taken with or without food.

Adult Dose

Oral
Uncomplicated skin and skin structure infections
Adult: 400 mg 12 hrly for 10-14 days.

Vancomycin-resistant Enterococcus faecium
Adult: 600 mg 12 hrly for 14-28 days.

Methicillin-resistant Staphylococcus aureus infections
Adult: 600 mg bid for 7-21 days.

Community-acquired pneumonia; Nosocomial pneumonia; Complicated skin and skin structure infections
Adult: 600 mg 12 hrly for 10-14 days.

Elderly: No dosage adjustment needed.

Hepatic impairment: Mild to moderate: No dosage adjustment needed.

Child Dose

Oral
For Pediatric Patients
Pneumonia, complicated skin infections, vancomycin resistant enterococci:
Birth–11 y: 30 mg/kg/day q8h
>11 y: 1,200 mg/day q12h

Uncomplicated skin infections:
Birth–5 y: 30 mg/kg/day q8h
5–11 y: 20 mg/kg/day q12h
>11–18 y: 1,200 mg/day q12h

Renal Dose

Renal impairment: No dosage adjustment needed.

Contraindication

Linzolid formulations are contraindicated for use in patients who have known hypersensitivity to Linzolid or any of the other product components. Linzolid should not be used in patients taking any medicinal product which inhibits monoamine oxidases A or B (e.g. phenelzine, isocarboxazid) or within two weeks of taking any such medicinal product. Linzolid should not be administered to patients with uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, carcinoid syndrome and/or patients taking directly and indirectly acting sympathomimetic agents (e.g. pseudoephedrine), vasopressive agents (e.g. epinephrine, norepinephrine), dopaminergic agents (e.g. dopamine, dobutamine), serotonin re-uptake inhibitors, tricyclic antidepressants, serotonin 5-HT1 receptor agonists (triptans), meperidine or buspirone.

Mode of Action

Linezolid is a bacteriostatic oxazolidinone which acts by inhibiting ribosomal protein synthesis. It is active against gm+ve bacteria including vancomycin-resistant enterococci and MRSA. It has limited in vitro activity against gm-ve bacteria.

Precaution

Preexisting myelosuppression, renal impairment (CrCl < 30ml/min), uncontrolled hypertension, phaeochromocytoma, carcinoid syndrome, untreated hyperthyroidism, chronic infection, history of seizures, bipolar depression, schizophrenia or acute confusional states. Pregnancy and lactation. Monitor complete blood counts weekly. Give after haemodialysis. Not known if linezolid or metabolites removed during peritoneal dialysis.

Lactation: Unknown; use caution

Side Effect

>10%
Pediatrics
Diarrhea (7.8-10.8%)

1-10%
Headache (5.7-8.8%).Diarrhea (8.2-8.3%),Nausea (5.1-6.6%),Vomiting (2-4.3%),Dizziness (1.8-2.6%),Rash (1.1-2.3%),Vaginal moniliasis (1.1-1.8%),Taste alteration (1-1.8%),Oral moniliasis (0.5-1.7%),Abnormal LFTs (0.4-1.6%),Fungal infection (0.3-1.5%),Localized abdominal pain (1.2-1.3%),Tongue discoloration (0.3-1.3%),Generalized abdominal pain (0.9-1.2%)

Pediatrics
Vomiting (2.9-9.4%),Headache (0.9-6.5%),Anemia (5.6%),Thrombocytopenia (4.7%),Nausea (1.9-3.7%),Generalized abdominal pain (0.9-2.4%),Localized abdominal pain (0.5-2.4%),Loose stools (1.6-2.3%),Eosinophilia (0.4-1.9%),Pruritus, other than application site (0.8-1.4%),Vertigo (1.2%)

<1%
Lactic acidosis,Myelosuppression,Peripheral neuropathy,Disorder of optic nerve,Serotonin syndrome

Potentially Fatal: Reversible myelosuppression including anaemia, leukopenia, pancytopenia and thrombocytopenia (particularly if using > 10-14 days), transient ischaemic attacks, renal failure, Stevens-Johnson syndrome.

Interaction

May reduce serum levels w/ rifampicin and phenytoin. May cause hypoglycaemia w/ insulin or oral antidiabetics. May increase risk of seizures w/ tramadol.

Potentially Fatal: Increased risk of serotonin syndrome w/ MAOIs, TCAs, SNRIs, or other serotonergic drugs (e.g. bupropion, vilazodone, mirtazapine, amoxapine, buspirone, maprotiline, meperidine, trazodone, nefazodone). Significant increase in BP w/ vasopressive agents (e.g. epinephrine, norepinephrine), sympathomimetic agents (e.g. pseudoephedrine) and dopaminergic agents (e.g. dopamine, dobutamine).