Omniclear 350

Introduction
Omniclear 350 is known as a contrast agent. It is injected into the body before an X-ray test to enhance the visibility of internal body structures. Omniclear 350 is injected by the doctor during the X-ray examination. The amount you are given will depend on what you are being treated for and how much you need for the examination procedure. The most common side effects of this medicine include nausea, vomiting and diarrhea. Most of these usually go away within a short time of the injection. If you are bothered by them or they go on for longer, talk to your doctor or nurse. It is advisable to stay hydrated before the procedure starts to prevent kidney damage. You should also tell your doctor if you are pregnant, planning to become pregnant or breastfeeding.

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Uses of Omniclear 350
Diagnostic agent
Side effects of Omniclear 350
Common
Nausea
Vomiting
Diarrhea
How to use Omniclear 350
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
How Omniclear 350 works
Iohexol belongs to a class of drugs known as radiographic contrast agents. It enhances imaging due to its high Iodine content attenuating the beam of X-rays during examination.
What if you forget to take Omniclear 350?
Not applicable. Omniclear 350 is given before imaging test, so it is important to take it at the time as advised by the doctor. If you miss the dose, your test results can be inaccurate.
Brief Description
Indication
Radiographic contrast medium for diagnostic procedures
Adult Dose
Intravascular Angiocardiography: ventriculography, pulmonary arteriography, venography & studies of collaterol arteries Ventriculography: 40 mL, range of 30-60 mL; may be repeated as needed, not to exceed 250 mL Selective Coronary Arteriography: 5 mL. range 3-14 mL per injection Aortic Root and Arch Study: 50 mL, range 20-75 mL, when used alone Pulmonary Angiography: 1 mL/kg Combined Angiographic Procedures: Multiple Procedures not to exceed 5 mL/kg or 250 mL Aortography and Selective Arteriography – Aorta: 50-80 mL – Major branches incl celiac, mesenteric arteries: 30-60 mL – Renal arteries: 5-15 mL; not to exceed 250 mL/Iohexol 350 when repeat injection indicated Cerebral Arteriography: Common Carotid Artery: 6-12 mL Internal Carotid Artery: 8-10 mL External Carotid Artery: 6-9 mL Vertebral Artery: 6-10 mL CT Scanning of the Body Head Imaging via injection: 70-150 mL (Iohexol 300); 80 mL (Iohexol 350) Body Imaging via injection: 50-200 mL (Iohexol 300); 60-100 mL (Iohexol 350) Digital Subtraction Iohexol 350 Usual amount used for IV digital technique is 30-50 mL Administer as bolus at 7.5-30 mL/sec using pressure injector Excretory Urography Iohexol 300/350: 200-350 mgI/kg body weight Hysterosalpingography Iohexol 300: 15-20 mL, but varies with anatomy and/or disease state

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Child Dose
Intravascular Iohexol 300/350 Angiocardiography: ventriculography, pulmonary arteriography, venography & studies of collaterol arteries Ventriculography: Iohexol 350: 1.25 mL/kg, range 1-1.5 mL/kg; not to exceed 5 mL/kg or 250 mL, when multiple injections given Iohexol 300: 1.75 mL/kg, range 1.5-2 mL/kg; not to exceed 6 mL/kg or 291 mL, when multiple injections given Pulmonary Angiography: 1 mL/kg Combined Angiographic Procedures – Multiple Procedures -Iohexol 350: Not to exceed 5 mL/kg or 250 mL -Iohexol 300: Not to exceed 6 mL/kg or 291 mL Aortography and selective arteriography: 1 mL/kg single inj dose; not to exceed 5 mL/kg or 250 mL CT Scanning of the Body Head imaging: 1-2 mL/kg; not to exceed 35 gI Iohexol 300 Body imaging via injection: 50-200 mL (Iohexol 300); 60-100 mL (Iohexol 350) Excretory Urography Iohexol 300: 0.5-3 mL/kg of body weight Infants/children: According to age and body weight Usual dose: 1-1.5 mL/kg; not to exceed 3 mL/kg

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Contraindication
Procedure-specific. Intrathecal: Myelography in significant local or systemic infection where bacteremia is likely; concurrent use with corticosteroids; repeat myelography in the event of technical failure (risk of overdosage). Hysterosalpingography: During menstrual period or when menstrual flow in imminent; presence of infection; pregnancy, 6 mth after termination of pregnancy or 30 days after conization or curettage.
Mode of Action
Allows for radiographic visualization through the opacification of vessels and anatomical structures in the path of flow of the contrast media.
Precaution
Asthma or a history of allergies (risk of anaphylactoid reactions is increased); compromised blood-brain barrier (severe neurotoxicity after intrathecal use); epilepsy and brain tumour (higher risk of convulsions); severe hepatic or renal impairment, diabetics with renal impairment, dehydration and others who may be at increased risk of renal failure; multiple myeloma (dehydration from use may cause precipitation of protein in the renal tubules, leading to anuria and fatal renal failure); severe hypertension; advanced cardiac disease; phaeochromocytoma; sickle-cell disease; hyperthyroidism; debilitated, severely ill, very old, or very young patients; occlusive vascular disease. Special care to ensure that 140 and 350 mg iodine/ml solutions are not given intrathecally. Adequate resuscitative facilities should be available when radiographic procedures are undertaken, and patients should be kept under observation for a suitable period after the procedure. Lactation: Not known; not recommended

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Side Effect
Flushing or a sensation of heat; pain, extravasation, thrombophlebitis at the inj site; nausea, vomiting, headache, and dizziness; urticaria, pruritus, pallor, sweating, metallic taste, weakness, coughing, rhinitis, sneezing, lachrymation, visual disturbances; hypotension, tachycardia, bradycardia, transient ECG abnormalities, haemodynamic disturbances; dyspnoea, bronchospasm, angioedema, severe urticaria; convulsions, paraesthesia, paralysis; acute renal failure; thromboembolism, disseminated intravascular coagulation, thrombocytopenia; hyperthyroidism, thyroid storm thyrotoxicosis. Potentially Fatal: Profound hypotension, pulmonary oedema, respiratory arrest, ventricular fibrillation, circulatory failure, cardiac arrest, coma.

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