Medicine Overview of Prostanil MR 0.4mg Capsule
Introduction
Prostanil MR is an alpha adrenergic antagonist that is used in the treatment of benign prostatic hyperplasia. It helps to relieve symptoms like difficulty in passing urine. However, it does not decrease the size of the prostate. Prostanil MR is advised to take it in a dose and duration as per prescription. It should be taken with food, but take at the same time regularly. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of
Uses of Prostanil MR
- Benign prostatic hyperplasia
Side effects of Prostanil MR
Common
- Retrograde ejaculation
- Dizziness
- Nasal congestion (stuffy nose)
How to use Prostanil MR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prostanil MR is to be taken with food.
How Prostanil MR works
Prostanil MR is an alpha blocker. It works by relaxing the muscles around the bladder exit and prostate gland so urine is passed more easily. This helps empty the bladder completely and reduces the need to pass urine frequently or urgently in BPH.
What if you forget to take Prostanil MR?
If you miss a dose of Prostanil MR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
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Veltam 0.4 Tablet MR helps in relieving the symptoms of enlarged prostate. It does not decrease the size of the prostate.
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Veltam 0.4 Tablet MR must be taken with food.
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You will feel better within hours or days of starting the treatment. Full effect is usually seen within 2 weeks.
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Veltam 0.4 Tablet MR may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
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If you are scheduled to undergo an eye surgery due to cataract or glaucoma, inform your eye doctor about the usage of Veltam 0.4 Tablet MR.
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Inform your doctor if you have ever been diagnosed with kidney or liver problems.
Brief Description
Indication
Benign prostatic hyperplasia
Administration
Prolonged release tab: May be taken with or without food. Swallow whole, do not chew/crush.
Cap: Should be taken with food. Take ½ hr following the same meal daily. Swallow whole, do not open/chew/crush.
Cap: Should be taken with food. Take ½ hr following the same meal daily. Swallow whole, do not open/chew/crush.
Adult Dose
Oral
Benign prostatic hyperplasia
Adult: 1 (400mcg) capsule once daily. If response is inadequate after 2-4 weeks, may be increased to 800 mcg once daily; if therapy is interrupted, should be resumed at 400 mcg once daily
Benign prostatic hyperplasia
Adult: 1 (400mcg) capsule once daily. If response is inadequate after 2-4 weeks, may be increased to 800 mcg once daily; if therapy is interrupted, should be resumed at 400 mcg once daily
Hepatic impairment
Mild to moderate: Dosage adjustment not necessary
Severe: Not studied
Renal Dose
Renal impairment
CrCl ?10 mL/min: Dosage adjustment not necessary
CrCl <10 mL/min: Not studied
CrCl ?10 mL/min: Dosage adjustment not necessary
CrCl <10 mL/min: Not studied
Contraindication
Hypersensitivity to sulfonamide, severe hepatic impairment, lactation. History of orthostatic hypotension.
Mode of Action
Tamsulosin is a selective alpha1 adrenoreceptor-blocking agent. Smooth muscle tone is mediated by the sympathetic nervous stimulation of alpha1 adrenoreceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck. Blockade of these adrenoceptors can cause smooth muscles in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and reduction in symptoms in BPH.
Precaution
Hypersensitivity to Tamsulosin Hydrochloride. A history of orthostatic hypotension; severe hepatic insufficiency. As with other alpha1 blockers, a reduction in blood pressure can occur in individual cases during treatment with Tamsulosin, as a result of which, rarely, syncope can occur. At the first signs of orthostatic hypotension (dizziness, weakness) the patient should sit or lie down until the symptoms have disappeared. And they should be cautioned to avoid situations where injury could result (like driving, operating machinery or performing hazardous tasks). Before therapy with Tamsulosin is initiated the patient should be examined in order to exclude the presence of other
Side Effect
>10%
Headache (19-21%),Orthostatic hypotension (6-19%),Rhinitis (13-18%),Abnormal ejaculation (8-18%),Dizziness (15-17%),Arthralgia (11%),Infection (9-11%)
Headache (19-21%),Orthostatic hypotension (6-19%),Rhinitis (13-18%),Abnormal ejaculation (8-18%),Dizziness (15-17%),Arthralgia (11%),Infection (9-11%)
1-10%
Asthenia (8%),Back pain (7-8%),Skin rash (7%),Pharyngitis (5-6%),Diarrhea (4-6%),Myalgia (5%),Chest pain (4%),Cough (3-4%),Somnolence (3-4%),Nausea (2-4%),Sinusitis (2-4%),Abdominal discomfort (2-3%),Bitter taste (2-3%),Decreased libido (1-2%),Insomnia (1-2%)
Interaction
Increased plasma concentration w/ strong CYP3A4 inhibitors (e.g. ketoconazole). Moderate CYP3A4 inhibitors (e.g. erythromycin), strong (e.g. paroxetine) or moderate (e.g. terbinafine) CYP2D6 inhibitors may increase exposure of tamsulosin. Increased plasma concentration w/ cimetidine. Additive effect w/ other ?-adrenergic blocking agents. Concomitant use w/ PDE5 inhibitors may lead to symptomatic hypotension. Decreased plasma concentration w/ furosemide.
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