Prulax 2

Introduction
Prulax 2 is a prescription medicine used in the treatment of constipation. It increases the release of certain chemical that improves the movement of food inside the intestine and helps to increase gastric emptying of both liquid and solid. Prulax 2 is taken with or without food in a dose and duration as advised by the doctor. The dose you’re given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. The most common side effects are headache, nausea, and abdominal pain. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. This medicine may cause diarrhea, so it is better to take plenty of fluids while taking this medicine as it may help to prevent dehydration. Before taking it, you should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you. You should avoid this medicine if you are suffering from bleeding ulcers of the stomach. Consult with your doctor if are pregnant or breastfeeding.

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Uses of Prulax 2
Constipation
Side effects of Prulax 2
Common
Headache
Nausea
Diarrhea
Abdominal pain
How to use Prulax 2
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prulax 2 may be taken with or without food, but it is better to take it at a fixed time.
How Prulax 2 works
Prulax 2 indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine.
What if you forget to take Prulax 2?
If you miss a dose of Prulax 2, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
Prulax 2 helps treat chronic constipation and improve bowel movements, when laxatives have failed to provide adequate relief.
It can be taken with or without food, at any time of the day.
It may cause diarrhea. Drink plenty of water and inform your doctor if it bothers you.
Inform your doctor if your constipation has not improved even after four weeks of taking this medication.
Brief Description
Indication
Chronic idiopathic constipation.
Administration
May be taken with or without food.
Adult Dose
Oral Chronic idiopathic constipation Adult: 2 mg once daily. Elderly: Initially, 1 mg once daily, may increase to 2 mg once daily if necessary. Hepatic Impairment Severe (Child-Pugh Class C): Initially, 1 mg once daily, may increase to 2 mg once daily if necessary.

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Renal Dose
Severe (GFR <30 mL/min/1.73 m2): 1 mg once daily. Patient on dialysis: Contraindicated. _ Contraindication Intestinal obstruction or perforation, obstructive ileus, active severe inflammatory bowel conditions (e.g. Crohn’s disease, toxic megacolon/megarectum, and ulcerative colitis). Renal impairment requiring dialysis. Pregnancy and lactation. Mode of Action Prucalopride is a selective 5-HT4 receptor agonist w/ prokinetic effect. It stimulates peristaltic reflex, intestinal secretions, and GI motility. Precaution Patient w/ history of arrhythmias or ischaemic CV disease, severe and unstable concomitant disease (e.g. cancer, AIDS, neurological or psychiatric, pulmonary, IDDM or other endocrine disroders). Severe hepatic (Child-Pugh Class C) and renal (GFR <30 mL/min/1.73 m2) impairment. Elderly. This drug may cause dizziness and fatigue, if affected, do not drive or operate machinery. Monitoring Parameters: Monitor bowel movement frequency. _ Side Effect Nervous: Headache, dizziness, fatigue, malaise, tremors. CV: Palpitations. GI: Nausea, abdominal pain and distention, diarrhoea, vomiting, flatulence, dyspepsia, anorexia, rectal bleeding, gastroenteritis. Genitourinary: Polyuria, pollakiuria. Musculoskeletal: Muscle spasm. Others: Fever. _ Interaction May decrease serum concentration of contraceptives (i.e. oestrogens, progestins). May enhance adverse effect of levosulpiride. Increased serum concentration w/ P-glycoprotein/ABCB1 inhibitors. Reduced effect w/ atropine-like substance.