Widebac IV Injection

Introduction
Widebac IV Injection is an antibiotic that fights bacteria. It is used to treat severe infections of the body like skin, intra-abdominal infections, and community-acquired bacterial pneumonia. It works by killing the bacteria that cause these problems. But, it will not treat a viral infection. Widebac IV Injection is commonly used to treat critically ill patients admitted to the hospital. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should have your injections at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed it, even if your symptoms quickly improve. If you stop taking it too early the infection may return or worsen. Some people may develop side effects like headache, vomiting, nausea, increased liver enzymes, stomach pain, and diarrhea. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away. It may also cause dizziness, so do not drive or do anything that requires mental focus. Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding or suffering from any liver problems or if you are allergic to any antibiotic. While using it, you may be advised blood tests to monitor your liver function.

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Uses of Widebac IV Injection
Severe bacterial infections
Side effects of Widebac IV Injection
Common
Headache
Vomiting
Nausea
Increased liver enzymes
Stomach pain
Diarrhea
How to use Widebac IV Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Widebac IV Injection works
Widebac IV Injection is an antibiotic. It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.
Quick Tips
Widebac IV Injection is an antibiotic that is usually only given in the hospital for serious infections.
Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn’t stop or if you find blood in your stools.
It may cause dizziness. Don’t drive or do anything that requires mental focus until you know how Widebac IV Injection affects you.
Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Complicated intra-abdominal infections; Complicated skin and skin structure infections, Community-acquired pneumonia
Administration
IV Preparation Reconstitute each vial with 5.3 mL NS or D5W to achieve a conc of 10 mg/mL IV Administration Infuse over 30-60 min

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Adult Dose
The recommended daily dose is as follows: Adults: The recommended dosage regimen for Tigecycline is an initial dose of 100 mg, followed by 50 mg every 12 hours. Intravenous (IV) infusions of Tigecycline should be administered over approximately 30 to 60 minutes every 12 hours. The duration of therapy should be guided by the severity and site of the infection and the patient’s clinical and bacteriological progress. The recommended duration of treatment with Tigecycline for complicated skin and skin structure infections or for complicated intra-abdominal infections is 5 to 14 days and for Community-acquired pneumonia is 7-14 days. Hepatic impairment: Mild to moderate: No dosage adjustment. Severe: 100 mg as a single dose, then 25 mg 12 hrly.

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Child Dose
<18 years: Safety and efficacy not established _ Renal Dose Renal impairment: No dosage adjustment needed. Contraindication Hypersensitivity. Hospital-acquired pneumonia and ventilator-associated pneumonia. Use during tooth development. Mode of Action Tigecycline is a glycylcycline antibiotic which prevents protein synthesis of the susceptible bacteria by binding to its 30s ribosomal subunit. It is generally considered as bacteriostatic agent; w/ bactericidal activity against S. pneumonia and L. pneumophilia. Tigecycline antibacterial activity covers facultative gm+ve (including MRSA, vancomycin-susceptible Enterococcus faecalis) and gm-ve bacteria, and anaerobic bacteria. Precaution Hypersensitivity to tetracyclines. Use tigecycline in situations when alternative treatments are not suitable. Patients w/ complicated intra-abdominal infections secondary to clinically apparent intestinal perforation. Hepatic impairment. Pregnancy and lactation. Side Effect >10% Nausea (29.5%),Vomiting (19.7%),Diarrhea (12.7%) 1-10% Infection (8.3%),Fever (7.1%),Abd pain (6.8%),Headache (5.9%),HTN (4.9%),Anemia (4.2%),Dizziness (3.5%),Dyspnea (2.9%),Pruritus (2.6%),Rash (2.4%),Hypotension (2.3%),Insomnia (2.3%)

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Interaction
Increased warfarin serum levels. May decrease efficacy of oral contraceptives.