Medicine Overview of Trofurit 40mg Tablet
Trofurit belongs to a group of medicines called diuretics or water tablets. It is used to reduce the swelling (edema) caused by too much water in the body in people who have heart failure, liver or kidney disease. This medicine is also used to treat high blood pressure.
Trofurit helps your body get rid of extra water and salt through urine. It may be used alone or in combination with other medicines as per the dose advised by your doctor. It can be taken with or without food and should be taken at the same time each day. It is best to avoid taking this medicine within 4 hours of your bedtime to prevent having to get up at night to urinate.
It is important to continue taking this medication even if you feel well. If you stop taking it without consulting your doctor, your condition may worsen. Lifestyle changes like reducing stress, restricting salt intake, and stopping smoking may help this medicine work better.
Common side effects of this medicine include headache, dizziness, dehydration, decreased blood pressure and stomach upset. These are usually mild and disappear after a short time. Consult your doctor if they bother you or do not go away.
Before taking this medicine, let your doctor know if you have any liver problems. Pregnant or breastfeeding women should also consult their doctor before taking it. Regular monitoring of kidney function tests and electrolyte levels is important while using this medicine. It may reduce the potassium level in your blood so your doctor may ask you to add potassium-rich foods to your diet (such as bananas, coconut water, etc.) or prescribe supplements.
- Hypertension (high blood pressure)
- Edema
- Dizziness
- Weakness
- Dehydration
- Decreased potassium level in blood
- Increased blood uric acid
- Decreased magnesium level in blood
- Increased thirst
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Take it in the morning with breakfast to avoid getting up at night to urinate.
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Monitor your blood pressure after starting Trofurit, and notify your doctor if it does not lower down.
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Consult your doctor if you experience dizziness, tiredness, or muscle weakness that does not go away.
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Take potassium supplements or potassium-rich diet (banana, spinach, coconut water, etc.) as Trofurit can decrease your potassium levels and lead to dehydration.
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You may be asked to get regular blood tests done to monitor your kidney function.
Oral
Resistant Hypertension
Adult: 20-80 mg PO divided q12hr
Edema
Edema associated with congestive heart failure (CHF), liver cirrhosis, and renal disease, including nephrotic syndrome
20-80 mg PO once daily; may be increased by 20-40 mg q6-8hr; not to exceed 600 mg/day
Elderly: Initially, 20 mg and titrate upward if needed.
Parenteral
Oedema associated with heart failure
Adult: 20-40 mg IV/IM once; may be increased by 20 mg q2hr; individual dose not to exceed 200 mg/dose
Refractory CHF may necessitate larger doses
Acute Pulmonary Edema/Hypertensive Crisis/Increased Intracranial Pressure
0.5-1 mg/kg (or 40 mg) IV over 1-2 minutes; may be increased to 80 mg if there is no adequate response within 1 hour;not to exceed 160-200 mg/dose
Hyperkalemia in Advanced Cardiac Life Support (ACLS)
40-80 mg IV
Hypermagnesemia in ACLS
20-40 mg IV q3-4hr PRN
Hepatic impairment: Monitor, especially with high dosages
Edema
Infants and children: 1-2 mg/kg IV/IM/PO once initially; increased by 1-2 mg/kg q6-8hr (PO) or 1 mg/kg q2hr (IV/IM); individual dose not to exceed 6 mg/kg
Neonates (<28 days): 0.5-1 mg/kg IV/IM q8-24hr; individual dose not to exceed 2 mg/kg
Resistant Hypertension
<1 year: Safety and efficacy not established
1-17 years: 0.5-2 mg/kg PO q24hr or q12hr; individual dose not to exceed 6 mg/kg/dose
Prostatic hyperplasia. Hepatic or renal impairment, gout, DM, impaired micturition. Infusion rate should not exceed 4 mg/min to reduce the risk of ototoxicity. Monitor fluid and electrolyte balance and renal function. May lower serum levels of calcium and magnesium, thus serum levels should be monitored. Pregnancy and lactation.
Lactation: Drug excreted into breast milk; use with caution; may inhibit lactation
>10%
Hyperuricemia (40%), Hypokalemia (14-60%)
Frequency Not Defined
Hyponatraemia, hypochloraemic alkalosis, headache, drowsiness, muscle cramps, hypotension, dry mouth, thirst, weakness, lethargy, restlessness, oliguria, GI disturbances, hypovolaemia, dehydration, hyperuricaemia, acute generalised exanthematous pustulosis, drug rash w/ eosinophilia and systemic symptoms, reversible or irreversible hearing impairment, deafness, tinnitus, severe anaphylactic or anaphylactoid reactions (e.g. w/ shock), Stevens-Johnson syndrome, toxic epidermal necrolysis; increased liver enzyme, cholesterol and triglyceride serum levels.
Potentially Fatal: Serious cardiac arrhythmias.
Pregnancy category: C; treatment during pregnancy necessitates monitoring of fetal growth because of risk for higher fetal birth weights
Lactation: Drug excreted into breast milk; use with caution; may inhibit lactation
Analgesics reduce natriuretic action of furosemide. Antagonises hypoglycaemic agents and drugs used for gout. Hyperglycaemia with antihypertensive agent diazoxide. Antagonises muscle relaxants. Increased risk of ototoxicity when used with aminoglycosides especially in renal impairment. May enhance nephrotoxicity of cephalosporins. Effects of antihypertensives enhanced. Action antagonised by corticosteroids. Phenytoin and indometacin may reduce effects of furosemide.
Potentially Fatal: May provoke severe hypotensive response with ACE inhibitors. NSAIDs inhibit diuretic and antihypertensive effects. Increased incidence of premature beats with cardiac glycosides.
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